VETRIFLEX®
Clinical strength joint support for cats and dogs

CURRENT JOINT THERAPIES MAY MASK THE PROBLEM WITHOUT ACTUALLY ADDRESSING THE CAUSE

The ingredients in VETRIFLEX® reduce pain and inflammation while repairing and restoring joint health.2-4 It's a joint effort.

VETRIFLEX® contains extensively researched ingredients including:

 

CurcuVET® (Curcumin Phytosome®

  • Mimics the anti-inflammatory activity of an NSAID3,5
  • Potent COX-2 inhibitor5

Perna canaliculus (GlycOmega™ green-lipped mussel)

  • With 57 nutritional factors
  • Improves articular cartillage viscosity, flexibility, and tensile strength4

Phytosome® technology

  • Powering curcumin, boswellia, and grape seed extract
  • Provides superior bioavailability6

Intervene early with clinically proven, all-natural, Health Canada–approved (NN. N9C8) VETRIFLEX® joint formula for cats and dogs.

 
 
Vetriflex packaging with treats

ANTI-INFLAMMATORY AND ANALGESIC ACTION OF AN NSAID

  • Extensive studies have proven CurcuVET® to be a potent COX-2 inhibitor.5
  • A recent study compared the bioactivity of CurcuVET® to NSAIDs, finding that CurcuVET® was effective in helping to maintain the markers associated with a normal inflammatory response in canines.2
  • Boswellia has been used in Indian Ayurvedic medicine for centuries for reducing pain and inflammation. In several studies, boswellic acids have been found to have anti-inflammatory activity similar to that of the NSAIDs used in conventional medicine.7
  • Unlike NSAIDs, the botanicals curcumin and Boswellia are well-tolerated and are unlikely to cause adverse effects on kidney function, or cause stomach irritation or ulceration.2,7,8

THE POWER OF PERNA

Perna canaliculus is a green-lipped mussel that is farmed in New Zealand from a sustainable source. It contains:

  • Essential Fatty Acids (Omega 3, 6, and 9): Natural anti-inflammatory components that are not produced by the body
  • Chondroitin Sulfates: The principal component of cartilage – the shock absorbers for joints
  • Hyaluronic Acid: Necessary for maintaining the proper viscosity of synovial fluid surrounding the joint
  • Natural Glucosamine: A key building block for healthy cartilage
  • Amino Acids: Contains all 21 essential and non-essential amino acids – the building blocks of all bodily tissue
  • Minerals: Important cofactors for bone and cartilage health4
Perna canaliculus (GlycOmega™ green-lipped mussel)
Perna canaliculus (GlycOmega™ green-lipped mussel)

Perna canaliculus (GlycOmega™) provides 

57

NUTRITIONAL FACTORS needed for improved viscosity, flexibility, and tensile strength of the articular cartilage.4

INCREASING THE BIOAVAILABILITY OF BOTANICALS:

Poor bioavailability of polyphenolics can be improved using the Phytosome® technology delivery system, a strategy that enhances the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. In the Phytosome® process, an ingredient becomes an integral part of the lipid membrane, thus improving its systemic bioavailability when administered orally.6

 

CURCUVET® (CURCUMIN PHYTOSOME®)

  • Pharmacokinetic studies demonstrate a nearly 30-fold increase in bioavailability when compared to standard curcumin extracts.9
  • The proprietary Phytosome® technology combines curcumin and phosphatidylcholine in a 1:2 ratio promoting efficient absorption across membranes. This produces significantly higher peak plasma concentrations and larger area under concentration-time curves (AUC).5

CASPEROME® (BOSWELLIA PHYTOSOME®)

  • The bioavailability of boswellic acids from Casperome® is greatly optimized both at the plasma and tissue levels.10
  • Studies show that serum levels of KBA (11-keto-ß-Boswellic acid) are increased sevenfold, and serum levels of ß-Boswellic acid can be increased threefold, when compared to non-formulated extract.10
 

LEUCOSELECT® (GRAPE SEED EXTRACT PHYTOSOME®)

  • Research has demonstrated LeucoSelect®‘s ability to reduce oxidative stress and support plasma antioxidant defenses, both in physiological and clinical conditions.11
PhytosomeComplex
Phytosomes bind an herbal extract to a phospholipid. This unique Phytosome® Complex easily crosses the gut barrier resulting in significantly higher blood levels of the ingredients they are attached to.

VETRIFLEX® IS CLINICALLY PROVEN:

VETRIFLEX® features the clinically proven GlycoFlex® 3 formula, which showed a 41% increase in hind leg strength in four weeks, plus additional herbal extracts.12

Peak Vertical Force

VetriFlex-Chart-PeakVerticalForce
Treatment dogs showed a 41% increase in peak vertical force after 4 weeks of treatment with GlycoFlex® 3 compared to pretreatment values.

Synovial Prostaglandin E2 Concentration

SynovialProstaglandinE2Concentration
After 6 weeks of treatment, mean synovial Prostaglandin E2 levels were significantly lower in the responder treatment group compared to the responder control group.
Grey Wolf Animal Health is proud to be the Canadian distributor of VetriSCIENCE®.

References

1. Grey Wolf Animal Health. (2022, June). Dr. Danielle Anderson discusses how VetriFlex compares to other joint supplements. [Video]. Vimeo.https://vimeo.com/725752702

2. Di Pierro, F., Rapacioli, G., Di Maio, E. A., Appendino, G., Franceschi, F., & Togni, S. (2013). Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva®), nimesulide, and acetaminophen. Journal of pain research, 6, 201–205. https://doi.org/10.2147/JPR.S42184
3. Colitti, M., Gaspardo, B., Della Pria, A., Scaini, C., & Stefanon, B. (2012). Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs. Veterinary immunology and immunopathology, 147(3-4), 136–146. https://doi.org/10.1016/j.vetimm.2012.04.001
4. Kendall, R. V., Lawson, J. W., & Hurley, L. A. (2000). New research and a clinical report on the use of Perna canaliculus in the management of arthritis. Townsend Letter for Doctors and Patients, 99–111.
5. Marczylo, T. H., Verschoyle, R. D., Cooke, D. N., Morazzoni, P., Steward, W. P., & Gescher, A. J. (2007). Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer chemotherapy and pharmacology, 60(2), 171–177. https://doi.org/10.1007/s00280-006-0355-x
6. Semalty, A., Semalty, M., Rawat, M. S., & Franceschi, F. (2010). Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals. Fitoterapia, 81(5), 306–314. https://doi.org/10.1016/j.fitote.2009.11.001
7. Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., & Li, J. (2020). Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC complementary medicine and therapies, 20(1), 225. https://doi.org/10.1186/s12906-020-02985-6
8. Maroon, J. C., Bost, J. W., & Maroon, A. (2010). Natural anti-inflammatory agents for pain relief. Surgical neurology international, 1, 80. 

9. Togni, S., & Appendino, G. (2013). Curcumin and joint health: From traditional knowledge to clinical validation. In R. R. Watson & V. R. Preedy (Eds.), Bioactive food as dietary interventions for arthritis and related inflammatory diseases (pp. 67-81). San Diego: Academic Press. 

10. Hüsch, J., Bohnet, J., Fricker, G., Skarke, C., Artaria, C., Appendino, G., Schubert-Zsilavecz, M., & Abdel-Tawab, M. (2013). Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome®) of Boswellia extract. Fitoterapia, 84, 89–98. https://doi.org/10.1016/j.fitote.2012.10.002

11. Mao, J. T., Xue, B., Fan, S., Neis, P., Qualls, C., Massie, L., & Fiehn, O. (2021). Leucoselect Phytosome Modulates Serum Eicosapentaenoic Acid, Docosahexaenoic Acid, and Prostaglandin E3 in a Phase I Lung Cancer Chemoprevention Study. Cancer prevention research (Philadelphia, Pa.), 14(6), 619–626. https://doi.org/10.1158/1940-6207.CAPR-20-0585

12. Martinez, S., McCormick, D., Powers, M., Davies, N., Yanez, J., Hughes, K., & Lincoln, J. (2006). The effects of Glyco FLEX® 3 on a stable stifle osteoarthritis model in dogs: a pilot study. [Study]. North American Veterinary Conference 2007, Orlando.