ANTIMICROBIALS CAN CAUSE HARM

Antimicrobials don't work for the majority of GI conditions and can cause severe short and long-term harm to the gut microbiome.1-7

Cat and dog walking next to eachother

ENTERO AID +GI™

ENTERO AID +GI™ is an all-natural, vegan Veterinary Health Product (NN.K5L1) authorized for sale by Health Canada. ENTERO AID +GI™ supports and maintains a healthy gut and bowel function, including normal stool quality and frequency.


For Dogs and Cats

ACTIVE INGREDIENTS​ PER 1 mL
Montmorillonite
400 mg
Dextrose
160 mg
Mannan oligosaccharides (MOS)
50 mg
Sodium chloride
30 mg
Potassium chloride
6 mg
Magnesium chloride, included hydrated forms
6 mg
L-Glutamine
2 mg
Enterococcus faecium DSM 10663/NCIMB 10415
49000000 CFU
pets-fibre-boost-pack-EN-RGB

FIBRE BOOST +GI™

FIBRE BOOST +GI™ is an all-natural, vegan Veterinary Health Product (NN.N7U8) authorized for sale by Health Canada. FIBRE BOOST +GI™ is a highly palatable, soluble and insoluble fibre supplement containing prebiotics, probiotics and minerals for promoting a strong immune system while maintaining a healthy microbiome to support gut and digestion, healthy anal glands and improved stool quality.

For Dogs and Cats

ACTIVE INGREDIENTS​ PER 1 SCOOP
Mannan oligosaccharides (MOS)
120 mg
Beta-1,3/1,6-glucan
100 mg
Zinc oxide
30 mg
L-Glutamine
30 mg
Avena sativa (Oat bran)
3330 mg
Montmorillonite
420 mg
Psyllium
210 mg
Selenium yeast
30 mg
Enterococcus faecium DSM 10663/NCIMB 10415
440000000 CFU
Lactobacillus acidophilus
2500000000 CFU
REQUEST A CALL FROM YOUR TERRITORY MANAGER

Antimicrobials are largely unnecessary in acute GI upset1,7,8

  • A study reviewed electronic health records of 3,189 cases of acute canine diarrhea in vet practices in the UK. While antimicrobials were prescribed in 49.7% of these cases, they found that only the provision of dietary modification advice and gastrointestinal nutraceuticals was positively associated with resolution of diarrhea. No such associations were found when antimicrobials were prescribed.2
  • There is minimal (if any) proven benefit of antibiotic use in dogs with uncomplicated acute diarrhea. There is no basis to support the routine prescription and use of antibiotics in these cases.6
  • Most cases of acute diarrhea are not due to pathogenic bacterial infections or are self-limiting, so antimicrobials are not indicated, do not hasten time to clinical resolution, and may cause further dysbiosis.9

There is no proven benefit for the use of antimicrobials for the treatment of acute GI upset1-3,6

  • A Consensus Statement of the American College of Veterinary Internal Medicine (ACVIM) advises that “Most bacterial enteropathogens are associated with self-limiting diarrhea, and injudicious administration of antimicrobials could be more harmful than beneficial ”.10
  • A double-blind placebo-controlled study showed there was no statistical difference between a commercial probiotic, metronidazole, and placebo. Dogs presenting with acute diarrhea achieved acceptable fecal consistency after 3.5 ± 2.2 days when receiving probiotic, 4.6 ± 2.4 days with metronidazole, and 4.8 ± 2.9 days with placebo.3

There are negative short and long-term effects of administering antimicrobials in healthy pets and those with underlying gastrointestinal disease1,4-8

  • Antimicrobials can have a profound negative impact on the microbiome.1,7
  • Opinions vary about the short and long-term effects of antibiotics on the microbiome, which plays an important role in health and immunity, but it’s clear that concern is warranted.6
  • At day 63 in a study using tylosin, some dogs’ microbiome had not recovered two months after oral tylosin exposure.4
  • Fecal dysbiosis index significantly increased in healthy dogs receiving metronidazole, indicating significant alterations in the microbiome structure and diversity, with some changes remaining up to 4 weeks after completion of antibiotic administration.5

Despite the frequency of antibiotic use for GI disease in dogs, there are relatively few indications for prescribing antimicrobials. Overuse could result in antimicrobial resistance and may have long-lasting effects on the host microbiome.6

Recommendations for the Management of GI Conditions in Pets

A CE accredited panel discussion included updated Recommendations for the Management of GI Conditions in cats and dogs.8 Presented by Key Opinion Leaders in the field of gastroenterology and education.

Susan Kilborn DVM, DVSc, Dipl. ACVIM

Susan Kilborn
DVM, DVSc, Dipl. ACVIM

Tatjana K. Mirkovic BSc, DVM, Dipl. ACVIM

Tatjana K. Mirkovic
BSc, DVM, Dipl. ACVIM

Irene Moore
DVM, MSc, BSc (Agr)

communivet logo

ENGAGING YOUR ENTIRE TEAM!

Tools for the Management of Mild Uncomplicated Acute GI Upset

WATCH THE PANEL DISCUSSION

It’s free, and only takes two minutes to register.

NEW ROADMAPS

Veterinary professionals need new roadmaps for the approach of acute GI upset and chronic enteropathy from a “Do No Harm” perspective.1,7,8 This means:

  • PAUSING antimicrobial use
  • Choosing safer options
  • Shortening the duration of diarrhea while avoiding harm to our patient
  • Reducing stress and discomfort for the pet and pet parent

ROADMAP FOR THE MANAGEMENT OF MILD ACUTE GI UPSET.1,8

Management of Mild Acute GI Upset1,8

  • Medical grade clay to reduce time to resolution of acute diarrhea
  • Synbiotics to enhance immune function and improve gut health
  • Diet and hydration support

ROADMAP FOR THE MANAGEMENT OF CHRONIC ENTEROPATHY.7

Extended roadmap

Management of Chronic Enteropathy7

  • Medical clays to help resolve acute flares quickly
  • Synbiotics to help correct dysbiosis and improve gut health
  • Mixed fibre diet or supplementation

PRO CARE +GI™ 

Veterinary Health Product (NN.N0W3) authorized for sale by Health Canada. A synbiotic containing two bacterial strains, prebiotics (MOS), and beta-glucans. Promotes intestinal health and well-being by encouraging healthy intestinal flora, supplying nutrients to the gastrointestinal tract and maintaining a healthy immune system.

ACTIVE INGREDIENTS​ PER 5 g
Dextrose
3.98 g
Mannan oligosaccharides (MOS)
0.25 g
Beta-1,3/1,6-glucan
0.15 g
Enterococcus faecium DSM 10663/NCIMB 10415
2450000000 CFU
CONTACT US

Grey Wolf Animal Health is proud to be the Canadian distributor of Cf Pharma.

greywolf-logo
CF Pharma Logo

References

  1. Kilborn S, Carioto L, Mirkovic T.K. (2022, March 9). Pet Parents Have Come to Expect and Even Demand Antimicrobials for Mild Acute GI Upset …How can we change the narrative? CommuniVET Webcast. 
  2. Singleton, D. A., Noble, P., Sánchez-Vizcaíno, F., Dawson, S., Pinchbeck, G. L., Williams, N. J., Radford, A. D., & Jones, P. H. (2019). Pharmaceutical Prescription in Canine Acute Diarrhoea: A Longitudinal Electronic Health Record Analysis of First Opinion Veterinary Practices. Frontiers in veterinary science, 6, 218. https://doi.org/10.3389/fvets.2019.00218
  3. Shmalberg, J., Montalbano, C., Morelli, G., & Buckley, G. J. (2019). A Randomized Double Blinded Placebo-Controlled Clinical Trial of a Probiotic or Metronidazole for Acute Canine Diarrhea. Frontiers in veterinary science, 6, 163. https://doi.org/10.3389/fvets.2019.00163
  4. Manchester, A. C., Webb, C. B., Blake, A. B., Sarwar, F., Lidbury, J. A., Steiner, J. M., & Suchodolski, J. S. (2019). Long-term impact of tylosin on fecal microbiota and fecal bile acids of healthy dogs. Journal of veterinary internal medicine, 33(6), 2605–2617. https://doi.org/10.1111/jvim.15635
  5. Pilla, R., Gaschen, F. P., Barr, J. W., Olson, E., Honneffer, J., Guard, B. C., Blake, A. B., Villanueva, D., Khattab, M. R., AlShawaqfeh, M. K., Lidbury, J. A., Steiner, J. M., & Suchodolski, J. S. (2020). Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. Journal of veterinary internal medicine, 34(5), 1853–1866. https://doi.org/10.1111/jvim.15871
  6. Grimes, M., & Lidbury, J. (2020, February 19). Antibiotics in canine GI disease: When to use and when to ditch. DVM 360. Retrieved June 6, 2022, from https://www.dvm360.com/view/antibiotics-in-canine-gi-disease-when-to-use-and-when-to-ditch
  7. Carioto L, Kilborn S, Mirkovic T.K. (2022, September 28). Changing the narrative. Tools for reducing use of antimicrobials for GI conditions in companion animals. CommuniVET Webcast.
  8. Kilborn S, Mirkovic T.K., Moore I. (2023, September 13). Tools to engage your entire team! Tools for the Management of Mild Uncomplicated Acute GI Upset. CommuniVET Webcast. https://www.communivet.com/en/ca/education/webcasts/improving-the-management-of-acute-gi-upsets
  9. Frey, E., Costin, M., Granick, J., Kornya, M., & Weese, J. S. (2022). 2022 AAFP/AAHA Antimicrobial Stewardship Guidelines. Journal of the American Animal Hospital Association, 58(4), 1–5. https://doi.org/10.5326/1547-3317-58.4.1
  10. Marks, S. L., Rankin, S. C., Byrne, B. A., & Weese, J. S. (2011). Enteropathogenic bacteria in dogs and cats: diagnosis, epidemiology, treatment, and control. Journal of veterinary internal medicine, 25(6), 1195–1208. https://doi.org/10.1111/j.1939-1676.2011.00821.x

Questions?

We’ve got answers! Contact your local Grey Wolf Animal Health rep or call 1-844-400-GWAH (4924).

To learn more, visit greywolfah.com.

Français